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Highly pathogenic avian influenza HPAI is often controlled through culling of poultry. Compensating farmers for culled chickens or ducks facilitates effective culling and control of HPAI.
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Large mouse litters are often culled based on the premise of better survival and growth for the remaining pups. In addition, a limited number of weanlings were evaluated until three months of age for growth, health and physiological measurements. Most measurements did not differ among the cull groups. These included mortality, organ weights adrenals, kidneys and testes , bone mineral density, percent fat, 12 of the 17 blood parameters, and three of the seven electrocardiographic EKG parameters. Several parameters, including five of the 17 blood parameters and four of the seven EKG parameters, showed statistical differences, but all values were physiologically normal. These results suggest that mice in culled litters do not demonstrate improved health compared with those in unculled litters. The edition of the Guide for the Care and Use of Laboratory Animals Guide 1 recommended that mice weighing less than 10 g, which includes newborns and most pups prior to weaning, be provided with
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